![]() Nonspecific binding occurs with the use of activated charcoal and intralipid therapy (e.g., lipophilic local anesthetics (LA) and non-LA drugs). Specific binding can be achieved by chelation (e.g., heavy metals), immunotherapy (e.g., digoxin), and bioscavenger therapy (e.g., organophosphorus (OP) compounds). This includes (a) decreasing the active toxin level, (b) blocking the site of action of the toxin, (c) decreasing the toxic metabolites, and (d) counteracting the effects of the toxin.Īntidotes act by four predominant mechanisms (A) Direct action on the toxin involves specific and nonspecific binding and enhanced elimination. 1) guide antidotal therapy in toxicology that result in the alteration of the toxin load and the duration of exposure and elevate the victim's threshold for toxicity. 1 These in turn depend on the type of toxin, the dose, the route of administration, lag time to presentation to a hospital, and pharmacokinetics (absorption, distribution, and elimination). Two main variables impact the harmful effect of a toxin on the body, namely the dose and the duration of exposure to the toxin. Antidotes, however, have a broader meaning in terms of altering the effect of a toxin. When one thinks of antidotes, one generally considers those that operate through a distinct logical mechanism such as naloxone and flumazenil that function as competitive receptor antagonists or vitamin K for warfarin overdose to overcome enzyme inhibition. 2 On the other hand, if unavailable or used inappropriately, the patient may suffer adverse effects from the poison or the antidote, respectively. ![]() When antidotes are administered appropriately, they may limit morbidity and mortality as demonstrated in paracetamol and digitalis overdose. In severe poisoning, the antidote is only an adjunct to supportive treatment and its use should not distract the physician from delivering adequate attention to airway, breathing, circulation, and decontamination. It must be stressed that the expected benefit of the antidote must be determined and weighed against the potential side effects and toxicity of the antidote. In a small proportion (<2%) of toxins, 1 antidotes have been identified. “Treat the patient, not the toxin” is hence the guiding dictum in clinical toxicology. The latter list by far exceeds the former and hence the most important guiding principle in such emergencies is good supportive care while the patient recovers. In general, toxic agents can be classified into two groups: those for which specific treatment exists and others for which there is no specific therapy. Toxicological emergencies are encountered frequently in intensive care unit (ICU) practice, either as a result of drug overdose (accidental or suicidal) or due to drug toxicity secondary to inappropriate drug dosing or drug interactions. This review provides an overview of the role of antidotes in poisoning. Vitamins such as vitamin K, folic acid and pyridoxine are used to antagonise the effects of warfarin, methotrexate and INH respectively in the setting of toxicity or overdose. Drugs such as atropine and magnesium are used to counteract the end-organ effects in organophosphorus poisoning. Drugs such as N-acetyl cysteine and sodium thiocyanate reduce the formation of toxic metabolites in paracetamol and cyanide poisoning respectively. naloxone, flumazenil) are other mechanisms by which antidotes act. oximes for organophosphorus poisoning) and competitive receptor blockade (e.g. ethanol for methanol poisoning), enhancement of enzyme function (e.g. In some situations, enhanced elimination can be achieved by urinary alkalization or hemadsorption. Specific binders include chelating agents, bioscavenger therapy and immunotherapy. The most commonly used non-specific binding agent is activated charcoal. ![]() Reduction in free toxin level can be achieved by specific and non-specific agents that bind to the toxin.
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Online condolences can be posted at www.wildefuneralhome. In lieu of flowers, memorial donations can be made in her memory to the PA Breast Cancer Coalition, 2397 Quentin Rd., Suite B, Lebanon, PA 17042 or the Brandywine River Valley Hospice, 121 Bell Tower Lane, Oxford, PA 19363. ![]() In order to protect those at risk, please wear a face mask and practice social distancing while at the funeral home. Interment will be private and at the convenience of the family. Friends and family are invited to attend a visitation period taking place from 9:30 AM until the start of the service. Parkesburg, PA with visitation from 10:00 AM to the time of the service. Funeral services will be held at 11 AM on Thursday, April 6, 2023, from the Wilde Funeral Home, 434 Main St., Parkesburg, Pennsylvania, 19365. Memorial services will be held on Saturday, Maat 12:00 noon at the Wilde Funeral Home, 434 Main St. Lammey and fiancé Margaret Wagner of Cochranville and one granddaughter Olivia Ann Lammey. ![]() and wife Amanda of Huntingdon, PA and Herbert V. Our entire staff is dedicated to the highest. Having served Georgetown and the surrounding areas since 1911, ours is a well known and respected firm, the oldest among current establishments. She enjoyed listening to music, trips to the ocean and mountains but most of all, she enjoyed spending time with her granddaughter. Stars and Stripes: Fly a flag in honor of your loved one over The National WWII Museum. When you entrust your funeral plans to us at Wilds Funeral Home, you receive a reverent and compassionate service according to your familys faith. She was employed for 25 years, by the Brandywine Hospital as a scheduling coordinator. Newcomer Funeral Obituaries in Dayton, OH. Petro Dero.Ĭarol was an area resident all her life and a 1970 graduate of the Coatesville Area High School. Wilde Age 93, of Monroe, died Sunday, Januat Pleasant View Nursing Home in Monroe. ![]() Born in Coatesville, she was the daughter of the late Charles M. Carol Ann Jackson, 69, of Cochranville, passed away on Tuesday, Februat the Chester County Hospital in West Chester, PA. ![]() ![]() ![]() The agreement also provides for significant obligations in respect of patent law, and related rights, such as data protection, and biologics. There has been concerns about how the Trans-Pacific Partnership will affect tobacco control measures – like graphic health warnings and plain packaging of tobacco products. The Trans-Pacific Partnership also contains significant provisions in respect of trade mark law – covering counterfeiting, cybersquatting, well known trade marks, geographical indications, and Internet Domain Names. The agreement contains a suite of copyright obligations – relating to copyright term extension online intermediary liability technological protection measures and civil and criminal copyright enforcement. The Trans-Pacific Partnership promises to be transformative in terms of the Intellectual Property Chapter. The Trans-Pacific Partnership is a sweeping trade agreement, covering a dozen countries across the Pacific Rim, including Canada, Mexico, Australia, New Zealand, and a number of Latin American and Asia-Pacific countries. This presentation concerns a work in progress of a book manuscript on the Trans-Pacific Partnership: Intellectual Property and Trade in the Pacific Rim. The Trans-Pacific Partnership: Intellectual Property and Trade in the Pacific Rim Her research explores the entanglement between technology and users’ practices in the cultural dynamics of race and racism online. She holds an MA from the Digital Methods Initiative, University of Amsterdam, and a BA in Journalism from the Autonomous University of Barcelona. ![]() I examine the uses of “El Negro de Whatsapp” in the specific context of Spain through an exploration of the appropriations of the meme that have circulated in Whatsapp groups I am a member of.Īriadna Matamoros Fernández is a Lecturer at the School of Communication and member of the Digital Media Research Centre(DMRC) at the Queensland University of Technology. Platformed racism is “a new form of racism derived from the culture of social media platforms ‒ their design, technical affordances, business models and policies ‒ and the specific cultures of use associated with them” (Matamoros-Fernandez, 2017, p. I argue that users’ appropriations of this meme – independently of their intent – and Whatsapp’s affordances enact “platformed racism” (Matamoros-Fernandez, 2017). This paper examines the racism enacted by the memetic appropriations of “El Negro de Whatsapp”. This Whatsapp meme is situated within broader ‘bait-and-switch’ internet pranks like rickrolling (Know your meme, Rickroll), which imply a post of something appearing to be one thing but which is really something else. “El Negro de Whatsapp” is a platform-specific meme particularly popular amongst Spanish and Latin-American Whatsapp users that involves the posting of a picture that looks legitimate in preview but when clicked on reveals a lurking image of a black man with disproportionate genitals. ‘El Negro De WhatsApp’ Meme and how it enacts racism September 28: Kelvin Grove Campus: Z9 607: 1-3pm (room TBC). Photo by Pawel Nolbert on Unsplash The second of our DMRC Fridays Seminar Series for 2018 takes place on September 28 with four exciting presentations! Join us to hear about the latest research being generated by Centre members and research students. ![]() ![]() It’s a solid combination that makes DaisyDisk good value for money. The licence also entitles you to install the app on up to 5 different Macs that use your Apple ID. With a one-off payment of $9.99, DaisyDisk is certainly an affordable way to optimise your Mac storage. The developers, Software Ambience Corp, have been around for a while now and also offer a selection of other apps to use on the Mac. Is DaisyDisk safe?ĭaisyDisk is a well-known, popular app that’s available on the Mac App Store and has been notarized by Apple. Instead you can use the interface to track down the largest offenders and quickly remove them to reclaim space. It’s intended very much as a manual app, in that there are no automated processes that will clear space for you. Each file can be previewed before you add it to the pile, just to make sure you’re not about to delete something that you’re mistaking for something else.ĭaisyDisk is a powerful and well designed tool that can help you manage your internal hard drive as well as a range of external storage mediums, including Thunderbolt, HDD, SSD, flash and network drives. It also means that you can review the collected items before dispensing with them and remove any that you decide you want to keep. This makes it easy to prune the contents of your hard drive without having to repeatedly delete individual files. To help make sense of it all, there’s also a list in the upper right corner that breaks down the contents of any segment you select, with the names of files, folders and their relevant sizes.Ī nice touch is that you can simply drag and drop segments into an area in the lower left, where they will be held until you want to get rid of them all by clicking the Delete button. Clicking on each segment reveals information about the contents, with individual sub-folders and files shown in a new circular graph so you can quickly see what’s using the most storage. The larger the segment, the more space it takes up on the drive. Requirements: macOS 10.10 or later (legacy versions available for earlier)ĭaisyDisk has a modern interface, in that it displays the contents of your hard drive in a circular graph that has colour coded segments of different sizes which represent the folders and data (Users, Library, System etc.).Distribution: Direct from DaisyDisk website or through the Mac App Store.Free trial: Yes, with feature limitations. ![]() Being so attached, you can imagine the separation anxiety pet parents experience when they're at work or vacationing for an extended amount of time. ![]() To alleviate this stress, a Minnesota-based startup has invented a two-way petcam that enables both owner and pet to connect and interact remotely in a manner similar to Skype or Apple’s FaceTime. ![]() The $350 PetChatz device features a "chew-proof" intercom-sized unit with a built-in speakerphone, camera system and interactive LCD screen that can be plugged into any wall outlet.Ĭonnected via Wi-Fi, owners would then use an app on their computer or mobile device to start a "chat" session, which can be recorded and shared with others. A special ring tone signals to the pet that someone's calling and an additional motion and sound detection system can be set up to notify parents of any activity around the house. While technically dogs or cats don’t have the ability to chat, people can use the "Greet & Treat" system to reward their pets by dispensing tasty treats and even special scents that are kept in a refillable hidden compartment. PetChatz was created by Mark Kroll, a medical technology developer with more than 350 patents to his name. He holds the title of Minnesota's most prolific inventor. The idea came to him about a decade ago when, while he was Skyping with his daughter, the family's labrador recognized her voice and came running into the room. Kroll later collaborated with veterinary technician Lisa Lavin to to develop PetChatz and other similar long-distance technologies under a new venture called Anser Innovation. We feel guilty when we're away on vacation and this is a way to alleviate that separation anxiety." "As a pet parent myself, I understand how strongly people feel about their pets," says Lavin, who estimates that she has spent a total of $11,200 on vet bills and $80 a month on dog food for both of her live-in poodles. If there is one aspect of these extravagant pet parenting products that some might find troubling, other than the cost, it's that promoting them involves a great deal of anthropomorphizing. Though dogs and cats are intelligent, they still aren't human, and treating them as such hints at a kind of resolute denial to accept the fact that they may not even enjoy being the benefactor of pricey skin treatments. Some experts think its a stretch to believe that the critter on the other end even recognizes a person being displayed on a screen. "This product introduces the potential for interaction between the dog and the technology," Margaret Duxbury, an animal behavior professor at the University of Minnesota, told the Star-Tribune a year ago. "It will certainly be disappointing if the dogs don't respond at all. Does that even matter if they respond to the voice?'' Perhaps they will respond to the voice but not recognize that the picture is of their owner. Lavin claims that the company has since tested the device, with pet and human subjects, and discovered that pets can be easily trained to at least recognize the ring in a manner similar to a Pavlovian response. (Some animals have even been trained to be government spies.) As for whether a pet knows who's on-screen, she says that would depend on how much visual technology the pet has been exposed to. "What we found was that the pet who spends a lot of time watching TV is more likely to be compelled to recognize your image on the screen and follow commands than one who doesn't," she says. What's important, she emphasizes, is that this device does more for the emotional welfare of the owner than for the pet. If there is any benefit for the pet (besides food), she adds, it's that the pet, especially dogs, receives some stimulation during the day, which animal behaviorists agree can do wonders for their well-being. PetChatz is slated to be available for purchase on the product's website and at select independent pets stores nationwide during the first quarter of 2014. ![]() There is a place to manually count how many of that gear set you own, what character is holding it, how much is in your stash and the total amount of armor you have for that gear set. The other way to utilize the manger is to go to each tab, delete in armor information I have and manually input your own. The number listed on the side arms combined with your primary/secondary is the total number of weapons on that character. The number listed on your primary and secondary is a duplicate. The manager tab will count this up and tell you the total amount of armor you have on that character. You can input the value of each item, 17 armor, 15 masks, 14 knee pads, 16 backpacks, 12 gloves 19 holsters. The number listed on your armor shows the number of armor on that character. The manager tab also has an area where you can manually count your loot based on the numbers listed next to each item category in your inventory screen. The manger tab will automatically count all the input loaded on each individual tab. Added locked sheets/cells to protect formulas. Adjusted numerous GUI aspects for ease of use.Ĭ. Added additional item counters to assist in identifying any errors in item locationī. Added weekly reset reminder and website link Ī. Added weekly activity counters to the manager tab for Weekly Assignments, Weekly HVTs, Incurions, Legendary Missions and DZ Landmarks.ī. Adjusted gear totals location on each tab to improve ease of tracking.Ī. Improved Performance and Stat Mods tracking. Improved Stat Rating identifiers to include ranges for classified gear. ![]() Each tab automatically calculates the player count totals for each item and automatically transposes that information to the item manger tab.į. Added Survival and Underground to the weekly activities counters.Į. Added additional date counters for resets to the item manager tab.ĭ. Improved manual item tracking per player by item type to automatically add up armor and weapons.Ĭ. All data entered on each tab automatically calculates on the Manager tab.ī. There is a tab for performance mods, stat mods, weapons, weapon mods, each gear set, all high end items, exotic armors, and the gear set bonuses. Manager Tab displays data regarding your entire inventory. The Division Inventory Manager Description. I hope it will help you save time and make managing your inventory just a little easier. I created this to help me manage my inventory. I uploaded a copy of the Item Manager I use to Google Drive. Rule 7 - LFG/Clan Recruitment Topic Filters: Discussion Rule 1 - Follow Reddiquette Rule 2 - Harassment & Witchhunting Rule 3 - Low Effort/Low Quality Rule 4 - Duplicates Bugs & Glitches Rule 5 - Self Promotion & Spam Rule 6 - Advertising, Selling etc. Keep it fun, keep it respectful and remember that in the end - it's just a game. The power to shape this community is in your hands. If you prefer using the mouse, tmux also allows that, although the mouse is disabled by default. Tmux is most often used with the keyboard, and it provides many keybindings to make it easier to execute commands, create new panes, and resize them. Ctrl+B W - Open a panel to navigate across windows in multiple sessions.įor additional keybindings, consult the tmux man pages.Ctrl+B : - Enter the command line to type commands. Tab completion is available.Ctrl+B 0 (1,2.) - Move to a specific window by number.Ctrl+B N or P - Move to the next or previous window.Ctrl+B Arrow Key (Left, Right, Up, Down) - Move between panes.Ctrl+B " - Split the window into two panes vertically.Ctrl+B % - Split the window into two panes horizontally.Ctrl+B D - Detach from the current session. ![]() You can name your session by passing the parameter -s to the tmux new command when creating a new session: $ tmux new -s Session1 Here are some of the most useful ones.įirst, create a new tmux session if you're not already in one. Tmux provides several keybindings to execute commands quickly in a tmux session. This functionality alone makes tmux a great tool, but it has even more to offer, including its default keybindings. You can type Ctrl+C to cancel it.Īll tmux commands can also be abbreviated, so, for example, you can enter tmux a , and it will work the same as tmux attach. When you're ready, reconnect to the server and reattach to the existing tmux session to resume where you left off: $ tmux attach -t 0Īs you can see, the command continued to run and print messages on the screen. You can disconnect your SSH connection at this point, and the command will continue to run. You can list active tmux sessions with tmux ls: $ tmux lsĠ: 1 windows (created Sat Aug 27 20:54:58 2022) You're no longer attached to the session, but your long-running command executes safely in the background. After that, press D to detach from the current session. Tmux operates using a series of keybindings (keyboard shortcuts) triggered by pressing the "prefix" combination. You can detach from your tmux session by pressing Ctrl+B then D. $ while true do echo "Hello $c" let c=c+1 sleep 1 done For example, to simulate a long-running process: $ c=1 Now that you're connected to tmux, you can run any commands or programs as you normally would. Here's an example of a customized tmux session: Scriptability, which allows me to create custom tmux sessions for different purposes.Some of tmux's features that help me and increase my productivity include: I've been using tmux on my laptops for over eight years. In addition to its benefits with remote connections, tmux's speed and flexibility make it a fantastic tool to manage multiple terminals on your local machine, similar to a window manager. Later, you can reattach tmux to the same or a different terminal. You can detach tmux from the current terminal, and all your programs will continue to run safely in the background. Tmux also decouples your programs from the main terminal, protecting them from accidentally disconnecting. ![]() ![]()
![]() If you have any other questions, most of them will be answered elsewhere in this post. In this section, I’ll briefly answer some of the most frequently asked questions about Skyline Drive in Shenandoah National Park, Virginia. ![]() Read this blog post to discover the greatest Skyline Drive viewpoints for fall colors! More than 1,400 vascular plants, including no fewer than 132 species of trees (more than all of Western Europe combined), and 1,650 non-vascular plants, such as mosses and lichens, contribute to the park’s impressive biodiversity.Īll these trees create a spectacularly colorful show in the fall. Valleys both wide and narrow characterize the landscape as well, cut out by mountain streams and waterfalls. ![]() Shenandoah National Park consists primarily of forest-covered hills and mountains-95% of the park is forested. No less than 40% of Shenandoah National Park’s surface area is federally designated wilderness.Įven though the park’s landscapes might not be as spectacular as those in some of the West Coast parks, it encompasses some seriously wild terrain. While Shenandoah National Park is sometimes seen as more of a tourist attraction than a protected nature reserve, it actually has one of the highest percentages of wilderness areas of all United States national parks. It is the only road through the park, accessible at four different entrances. Skyline Drive traverses Shenandoah National Park along the long and narrow crest of the Blue Ridge Mountains. Keep in mind, though, that there’s only one (expensive) gas station in Shenandoah National Park, so you’re advised to fill up on fuel before entering the park. You can cover all of Skyline Drive’s 105 miles in just a few hours, but it is highly recommended to set aside at least a full day-but preferably two or more-to explore this phenomenal mountain road. What Is the Best Time to Drive Skyline Drive?.How Long Does It Take to Drive Skyline Drive?.Places To Stay In/Near Shenandoah National Park.Visit Big Meadows and the Byrd Visitor Center.Hike a Section of the Appalachian Trail.Shenandoah National Park Skyline Drive Guide 2023.Black Canyon of the Gunnison National Park, CO.Great Smoky Mountains National Park, NC/TN. ![]() The steering is well weighted too, and there’s a linear feel to the brake pedal despite its regenerative properties.Īll-in-all you can sense that this hybrid system is an extremely clever one, even if it’s meant to be a cheaper alternative, and it being made obvious really isn’t an issue. There are three drive modes – the aforementioned ‘Pure’ as well as Sport (does what it says on the tin) and MySense which optimises for efficiency in hybrid driving. It’s nothing to be alarmed about though, and listening to the drivetrain to work out what it's doing at which point in time becomes an interesting way to pass the time. The engine speed will generally match road speed pretty well and only sounds a little strange as it keeps spinning just a second longer than you’d expect after lifting off.ĭrain the battery and you’ll also get a slightly different noise as the four-cylinder ICE transforms into a generator – sending its power directly to the battery to ensure you’ve got enough charge to always start the car in EV only mode. Gearchanges are smooth and there’s far less of a rubber band rev effect than you’d get with a CVT-equipped hybrid system. For a more detailed look at the Captur plug-in, read on for the rest of our review.Well, it’s all very impressive. ![]() Overall, the Capture E-TECH is a solid plug-in hybrid SUV that should suit company-car users with smaller families down to the ground – and will also appeal to private buyers who do urban miles but need the flexibility of petrol power. A five-year/100,000-mile warranty ensures peace of mind, while a free BP Pulse wallbox home charger helps to sweeten the deal. ![]() It's a slick system that really lifts the interior ambiance, as well as offering control over the car's hybrid functions.Įlsewhere, Renault's reputation for safety is upheld: the Captur plug-in boasts a strong Euro NCAP crash-test rating and comes with a long list of safety and driver-assistance features. All are well equipped and get our preferred, larger 9.3-inch touchscreen infotainment system complete with Apple CarPlay, Android Auto and internet connectivity. There are currently three trim levels available: Evolution, Techno and E-TECH Engineered. However, in hybrid mode the two power sources can feel a little mismatched: the switch between petrol and electric power is far more noticeable than in the non-plug-in Clio. On the move, the Captur plug-in hybrid is particularly enjoyable in pure-electric mode, offering smooth and quiet progress for up to 32 miles – very useful for shorter journeys and urban crawls. And with those seats pushed all the way back, rear-seat occupants get acres of legroom. The car now boasts one of the best interiors in the class – one that can challenge the class above for fit and finish.īoot space is down considerably on petrol and diesel versions due to the car's 9.8kWh battery, but the rear bench slides forwards and back to help maximise the room on offer. Renault has revamped its small SUV for this generation and the results are welcome – a high-quality interior with versatile rear seating features, along with much-needed improvements to the infotainment. It's one of the smaller plug-ins on the market and so is particularly efficient – on paper at least. Unlike the Clio E-TECH supermini, which offers no meaningful pure-electric range and can't be plugged in to charge, this Captur E-TECH SUV is a full plug-in capable of up to 32 miles of electric driving and CO2 emissions from 34 to 36g/km. Renault – maker of the ZOE EV – has found a way to make normally pricey plug-in hybrid technologyĪffordable. ![]() ![]() In the original manga, Star Platinum, early on, is seen with a wide, disconcerting smile. Star Platinum demonstrates a sort of interest in self-preservation, as seen when it halts a bullet Jotaro experimentally shoots at his own head, protects an incapacitated Jotaro from DIO's attacks during Time Stop, and revives him from near-death by directly pumping his heart (however, considering Star Platinum's pioneering role in the series, this capacity may speak primarily to the metaphysical or subconscious qualities of Stand users). It has a very malicious grin when it is first revealed. With a relatively human face, it may scowl and smile. It is silent, except when it throws punches, during which it cries "ORAORAORA" loudly and repeatedly. Jotaro has described Star Platinum as very violent. Having the same bluish-purple kind of skin tone, and similar hairstyle and gloves. Star Platinum bears a similar appearance to Ikuro Hashizawa as Baoh in Baoh: The Visitor. Its darker purple highlights, such as those under its eyes, also become a sky blue color. In the anime and film adaptations of Part 4, all of Star Platinum's clothing, such as its red scarf and black gloves, become white, reflecting Jotaro's own transition from black to white apparel. The spiral patterns symbolize the Ripple and the concept of infinity. Its shoulder pads resemble the ones worn in Hokuto no Ken (Fist of the North Star). Star Platinum was designed to look like a guardian spirit. It has a minimal range of clothing and armor, including a short, circular scarf, shoulder pads with a spiral design, long gloves with studs on the back, knee and elbow guards, a loincloth, and short boots (which became knee-length as of Part 6). Initially, its facial features were very similar to Jotaro's.Ī wavy line runs from each arm to the front of its torso, continuing down its legs. It wears a cap on its chin, and a metallic headband in three pieces, the central piece of which is shaped as a vertical ellipse. The spaces under its eyes and on its cheeks and chin are a darker color and divided clearly from the space around its nose and mouth. It has long, flowing hair with a darker shade above its eyes and on the bridge of its nose, blurring the distinction between its hair and head. In colored art, its skin is often a hue between purple, blue, green, and small bits of gold. Star Platinum is a humanoid Stand, resembling a tall, well-built man of similar proportions to Jotaro, if not more muscular. |
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